Clone ID: EP192Y
Antibody Type: Rabbit Monoclonal IgG
Catalog#: 2218-1
Size: 100ul
Recommended Applications: WB
Species Reactivity: Human, Mouse, Rat
Mol. Weight: 185 kDa
UniProt ID: Q15303
Alternative names: p180erbB4, Tyrosine kinase-type cell surface receptor HER4
Description: HER4 / ErbB4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. erbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). erbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).
Specificity: A synthetic peptide near the C-terminus (cytoplasmic domain) of human Her4/ErbB4 was used as immunogen.
Recommended Dilutions:
WB: 1:1000 - 2000
|
|
|
|
A. Western blot analysis on human brain tissue lysate using anti-Her4/c-erb-4 RabMAb (cat. # 2218-1), dilution 1:2000 |
|
Description References:
| 1. |
Plowman, G.D., et al. Proc Natl Acad Sci U S A. 90: 1746 |
| 2. |
Elenius, K., et al. J Biol Chem. 272: 26761 |
| 3. |
Garcia, R.A., et al. Proc Natl Acad Sci U S A. 97: 3596 |
*Determined species reactivity – for other species not listed cross reactivity may be possible but not tested.